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KMID : 1011320180100020049
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Journal of Pharmacoepidemiology and Risk Management
2018 Volume.10 No. 2 p.49 ~ p.53
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Approaches to the Diagnosis and Management of Hypersensitivity Reactions to Aspirin and Nonsteroidal Anti-inflammatory Drugs
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Kang Sung-Yoon
Lee Sang-Pyo
Lee Sang-Min
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Abstract
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Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used due to their antipyretic, analgesic, and anti-inflammatory effects. However, both aspirin and NSAIDs cause adverse reaction with an array of symptoms from mild cutaneous and gastrointestinal irritation to life-threatening anaphylaxis. NSAIDs-induced hypersensitivity reactions may be related to immunologic and non-immunological mechanisms. Although the roles of blood and skin tests are limited, the diagnosis can be established by obtaining a careful history and physical examination. Further evaluation including in oral or bronchial provocation test may be necessary to perform under the control of a skilled physician and a well-equipped facility. Given severe NSAIDs-induced hypersensitivity reactions, avoidance of the causative NSAIDs and all cross-reactive NSAIDs is the cornerstone of management. However, when treatment with aspirin or NSAIDs is necessary, desensitization can be performed.
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KEYWORD
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Aspirin, Nonsteroidal anti-inflammatory drugs, Adverse reaction, Hypersensitivity reaction, Desensitization
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